W. Alexander Donald

W. Alexander Donald

W. Alexander Donald

B.Sc. Seattle University 2005, Ph.D. University of California, Berkeley, 2010

Associate Professor

Contact details

Phone: +61 2 9065 9401
Email: w.donald@unsw.edu.au


Science & Engineering Building (E8), Room 601

Research Group Website


Biographical Details

Dr William (Alex) Donald is a research and teaching academic in the School of Chemistry at the University of New South Wales who is developing and applying analytical and mass spectrometry methodologies with an emphasis on problems in chemistry and biochemistry. 

Graduate of University of California, Berkeley (Ph.D., 2010)

Postdoctoral Fellow & Centenary Research Fellow, University of Melbourne (2010-2012)

Lecturer, University of New South Wales (2013-2016)

Senior Lecturer, University of New South Wales (2016-2019)

Associate Professor, University of New South Wales (2020-)


International Union of Pure and Applied Chemistry Prize for Young Chemists (2011)

New South Wales Fresh Science Finalist (2013)

ARC Discovery Early Career Researcher Award (2013-2015)

Michael Guilhaus Research Award, Australian and New Zealand Society for Mass Spectrometry  (2015) 

Emerging Investigator, Analytical Methods (2015)

Emerging Investigator, Analyst (2016)

RACI Physical Chemistry Division Lectureship (2016)

RACI Analytical and Environmental Chemistry Division Peter W. Alexander Medal (2016)

Emerging Investigator, Journal of the American Society for Mass Spectrometry (2017)

Bowie Medal, Australian and New Zealand Society for Mass Spectrometry (2019)

ARC Future Fellowship (2020-2024)

Service Roles and Professional Organisations

Treasurer, Australian and New Zealand Society for Mass Spectrometry

Chair, Royal Australian Chemical Institute, NSW Analytical and Environmental Chemistry Group

Associate Editor, Journal of Enzyme Inhibition and Medicinal Chemistry

Editorial Board (Diagnostics and Bioanalytical Chemistry), Expert Opinion on Therapeutic Patents

Editorial Board, Journal of Enzyme Inhibition and Medicinal Chemistry

Book Editor, Comprehensive Analytical Chemistry 

Member, Royal Australian Chemical Institute

Member, Australian and New Zealand Society for Mass Spectrometry


Course Coordinator and Lecturer, Advanced Instrumental Analysis (Third Year Level)

Lecturer, Analytical Chemistry: Essential Methods (Second Year Level)

Current Research Grants

WA Donald, CT Supuran; Ultrasensitive chemical analysis of single cells by mass spectrometry; ARC Discovery Project; 2019-2021

WA Donald, CT Supuran; Rapid, Ultra-sensitive Protein Structure Elucidation by Mass Spectrometry; ARC Discovery Project; 2016-2018

NSW Smart Sensing Network

Selected Publications

1. Nguyen, G. T. H.; Tran, T. N.; Podgorski, M. N.; Bell, S. G.; Supuran, C. T.; Donald, W. A. Nanoscale ion emitters in native mass spectrometry for measuring ligand-protein binding affinities. ACS Central Science, 2019, 5, 308-318.

2. Winter, D. L.; Wilkins, M. R.; Donald, W. A. Differential ion mobility-mass spectrometry for detailed analysis of the proteome. Trends in Biotechnology, 2019, 37, 198-213.

3. Zenaidee, M. A.; Leeming, M. G.; Zhang, F.; Funston, T. T.; Donald, W. A. Highly charged protein ions: The strongest organic acids to date. Angewandte Chemie International Edition, 2017, 56, 8522-26 ("Very Important Paper").

4. Kabir, K. M. M.; Donald, W. A. Microscale differential ion mobility spectrometry for field deployable chemical analysis. Trends in Analytical Chemistry, 2017, 97, 399-427.

5. Dumlao, M. C.; Xiao, D.; Zhang, D.; Fletcher, J.; Donald, W. A. Effects of different waveforms on the performance of active capillary dielectric barrier discharge ionization mass spectrometry. Journal of the American Society for Mass Spectrometry, 2017, 28, 575-78 (Cover of Emerging Investigator Issue).

6. Leeming, M. G.; Donald, W. A.; O'Hair, R. A. J. Non-targeted identification of reactive metabolite protein adducts. Analytical Chemistry, 2017, 89, 5748-56.

7. Dumlao, M. C.; Jeffress, L. E.; Gooding, J. J.; Donald, W. A. Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures. Analyst, 2016, 141, 3714-21 (Emerging Investigator Issue).

8. Leeming, M. G.; Isaac, A. P.; Pope, B. J.; Cranswick, N.; Wright, C. E.; Ziogas, J.; O'Hair, R. A. J.; Donald, W. A. High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing. Analytical Chemistry, 2015, 87, 4104-09.

9. Zenaidee, M. A.; Donald, W. A. Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation. Analytical Methods, 2015, 7, 7132 (Emerging Investigator Issue).

10. Teo, C. A.; Donald, W. A. Solution Additives for Supercharging Proteins Beyond the Theoretical Maximum Proton-Transfer Limit in Electrospray Ionization Mass Spectrometry. Analytical Chemistry, 2014, 86, 4455-62.

Complete publication list: