J. Justin Gooding

J. Justin Gooding

J. Justin Gooding

B.Sc. (Hons) Melb. 1988, D. Phil. (Oxon) 1994, FAA, CChem, FRACI, FRSC, FRSNSW, FISE

Scientia Professor and founding co-director of The Australian Centre for NanoMedicine

Contact details

Phone: (02) 9385 5384
Email: justin.gooding@unsw.edu.au
Fax: (02) 9385 6141

Office

Room 743, Hilmer Building, E10
UNSW, Kensington 2052

Research Group Website

/research/research-groups/gooding-group

Biographical Details

Graduate of Oxford University (D. Phil., 1994). Postdoctoral Fellow, University of Cambridge, (1994-1996). Vice-Chancellor's Postdoctoral Research Fellow, UNSW (1997-1998). Lecturer, Flinders University of South Australia (1998). Appointed Lecturer at UNSW (1999), Senior Lecturer (2002), Associate Professor (2006), Professor (2006), UNSW Scientia Professor (2011). He is an NHMRC Investigator Awrd Holder, a Fellow of the Australian Academy of Science, a FEllow of teh Australian Academy of Technology and Engineering, a Fellow of the International Society of Electrochemistry, a Fellow of the Royal Society of Chemistry, a Fellow of the Royal Australian Chemical Institute and a Fellow of the Royal Society of New South Wales.

He is a former ARC Australian Laureate Fellow (2015-2020). He has also been the recipient of a NSW Young Tall Poppy Science Prize (2004), Alexander von Humboldt Fellowship (2005), University of Canterbury Erskine Fellow (2007), Royal Australian Chemical Institute Analytical Chemistry Division Lloyd Smythe Medal (2007), Eureka Prize for Scientific Research (2009), ARC Australian Professorial Fellow (2010-2104), Royal Australian Chemical Institute H.G. Smith Medal (2011), Royal Australian Chemical Institute Electrochemistry Division R.H. Stokes Medal (2012), Royal Society of Chemistry Australasian Lecturer (2012), NSW Science and Engineering Award for Emerging Research (2013). the Faraday Medal of the Royal Society of Chemistry Electrochemistry Division (2016), the  Biosensors and Bioelectronics Award (2016), the Walter Burfitt Prize for Science (2016) and Archibald Liversidge Medal for Chemistry (2016) both of the Royal Society of New South Wales, the 2017 Eureka Prize for Outstanding Mentor of Young Researchers and the 2017 Katsumi Niki Prize in Bioelectrochemistry from the International Society of Electrochemistry and the 2020 Jaroslav Heyrovsky Prize for Molecular Electrochemistry from the International Society of Electrochemistry

Chair, The Royal Australian Chemical Institute Electrochemistry Division 2006-2011, Inaugural Australian Representative of the International Society of Electrochemistry 2011-2012, Vice President International Society of Electrochemistry 2013-2015. He is a founding co-Director of the Australian Centre for NanoMedicine and the New South Wales Smart Sensing Network.

Research Interests

Our research group specialises in the molecule level modification of surfaces using self-assembled monolayers, biological molecules and nanomaterials to impart a desired functionality to that surface such as to:

1. Selectively detect an analyte – biosensors and nanodiagnostics

2. Influence biological processes – biomaterials and nanotherapeutics

3. Develop in vitro models of biological systems - 3D biopriting of organoids

4. To control electrochemical reactiosn at surfaces - electrocatalysis with nanoparticles.

The group is also part of the Australian Centre for NanoMedicine of which Professor Gooding is one of the three directors. As a result much of our research has a nanomedicine focus where we modify surfaces for diagnostic devices, imaging and biomaterials as well as more fundamental work on electron transfer, catalysis and cell-surface interactions.

1.Immunosensors for the detection of small molecules and for protein biomarkers.

2.Electrochemical detection of MicroRNA in clinical samples (with Professor Maria Kavallaris, Medicine UNSW).

3.Enzyme like nanoparticles for electrocatalysis (with Professor Richard Tilley UNSW and Professor Wolfgang Schuhmann (Bochum Germany)

4.Nanoparticle based biosensors for ultrasensitive detection for medical diagnostics (with Professor Rose Amal, Chemical Engineering, UNSW).

5.Nanostructured surfaces for understanding fundamental cellular processes (with Professor Katharina Gaus, Medicine UNSW and Professor Richard Tilley UNSW).

6.The 3D printing of cell cultures (with Professor Maria Kavallaris, Medicine UNSW).

7.Electrochemistry and molecular electronics on silicon surfaces (with Dr Simone Ciampi, University of Wollongong).

8.The immobilisation of homogeneous catalyst on surfaces (led by Professor Barbara Messerle, Macquarie University).

Research Group and Outputs

The research group is typically over 40 people in size with 10 post-docs, 25 or so Ph.D. students and 3-4 honours students and visitors. We create a supportive environment where all researchers work in teams on related projects with junior researchers being assisted by post-docs and senior Ph.D. students as well as Prof. Gooding. As our research involves a range of techniques all researchers acquire a broad range of skills but typically specialise in one or two techniques. Ph.D. students usually complete within 3½ years with 5-10 research publications. Using our team-oriented approach our research group has published over 100 papers within the last five years. Representative publications are listed below.

Selected Recent Publications

  • Y.F. Wu*, Y. Yao, S. Cheong, R.D. Tilley, J.J. Gooding*, Fabrication of Gold Metallized Nanopores in Silicon Nitride Membranes and Site-Specific Functionalities for Attomolar Detection of Proteins, Chem. Sci. 11 12570-12579 (2020).
  • R.H. Utama, L. Atapattu, A.P. O’Mahony, C.M. Fife, J. Baek, T. Allard, K.J. O’Mahony, J. Ribeiro, K. Gaus, M. Kavallaris*, J.J. Gooding*, Precise, high-throughput production of multicellular spheroids with a novel 3D bioprinter, iScience 23 101621 (2020).
  • Y.F. Wu, D. Bennett, R.D. Tilley, J.J. Gooding*, How Nanoparticles Transform Single Molecule Measurements into Quantitative Sensors, Adv. Mater. 32 1904339 (2020).
  • P.B. O’Mara, P. Wilde, T.M. Benedetti, C. Andronescu, S. Cheong, J.J. Gooding, R.D. Tilley, W. Schuhmann, Cascade Reactions in Nanozymes: Spatially Separated Active Sites inside Ag Core-Porous Cu Shell Nanoparticles for Multistep Carbon Dioxide Reduction to Higher Organic Molecules, J. Am. Chem. Soc. 141 14093-14097 (2019).
  • K. Chuah, Y. Wu, S.R.C. Vivekchand, K. Gaus, P.J. Reece, A.P. Micolich, J.J. Gooding, Nanopore Blockade Sensors for Ultrasensitive Detection of Proteins in Complex Biological Samples, Nature Comm. 10 2109 (2019).
  • R. Tavallaie, J. McCarroll, M. Le Grand, N. Ariotti, W. Schuhmann, E. Bakker, R.D. Tilley, D.B. Hibbert, M. Kavallaris, J.J. Gooding, DNA-programmed electrically reconfigurable network of gold-coated magnetic nanoparticles enables ultrasensitive microRNA detection in blood, Nature Nanotech. 13 1066-1071 (2018).
  • T.M. Benedetti, C. Andronescu, S. Cheong, P. Wilde, M. Kientz, R.D. Tilley, W. Schuhmann, J.J. Gooding, Electrocatalytic nanoparticles that mimic the three dimensional geometric architecture of enzymes: Nanozymes, J. Am. Chem. Soc. 140 13449-13455 (2018).
  • M. Faria, M. Björnmalm, K. Thurecht, S. Kent, R. Parton, M. Kavallaris, A. Johnston, J.J. Gooding, S. Corrie, B.J. Boyd, P. Thordarson, A. Whittaker, M. Stevens, C. Prestidge, C. Porter, W. Parak, T.P. Davis, E. Crampin, F. Caruso, Minimum information reporting in bio-nano experimental literature Nature Nanotech. 9 777-785 (2018).
  • S.G. Parker, Y. Yang, S. Ciampi, B. Gupta, K. Kimpton, F.M. Mansfeld, M. Kavallaris, K. Gaus, J.J. Gooding, A unique photoelectrochemical platform for the capture and release of rare single cells, Nature Comm. 9 Art. No. 2288 (2018).
  • E. Hinde, K. Thammasiraphop,H.T.T. Duong, J. Yeow, B. Karagoza, C. Boyer, J.J. Gooding, K. Gaus, Pair-correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release, Nature Nanotech. 12 81-89 (2017).
  • J.J. Gooding, K. Gaus, Single molecule sensors: challenges and opportunities for quantitative analysis, Angew. Chem. Int. Ed. 55 11354-11366 (2016).
  • Y.H. Zheng, A. Soeriyadi, L. Rosa, S.H. Ng, U. Bach, J.J. Gooding, Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection, Nature Comm. 6 Art. No. 8797 (2015).
  • X. Cheng, E. Hinde, D.M. Owen, S.B. Lowe, P.J. Reece, K. Gaus, J.J. Gooding, Enhancing Quantum Dots for Bioimaging using Advanced Surface Chemistry and Advanced Optical Microscopy: Application to Silicon Quantum Dots (SiQDs), Adv. Mater. 27 6144-6150 (2015).
  • D.J. Williamson, D.M. Owen, J. Rossy, M. Wehrmann, A. Magenau, J.J. Gooding, K. Gaus, Pre-existing LAT clusters do not participate in early T cell signaling events, Nature Immunology 12 655-662 (2011).