W. Alexander Donald

W. Alexander Donald

W. Alexander Donald

B.Sc. Seattle University 2005, Ph.D. University of California, Berkeley, 2010

Senior Lecturer

Contact details

Phone: 02 9385 8827
Email: w.donald@unsw.edu.au


Dalton 221 

Research Group Website


Biographical Details

Dr William (Alex) Donald is a research and teaching academic in the School of Chemistry at the University of New South Wales who is developing and applying analytical and mass spectrometry methodologies with an emphasis on problems in chemistry and biochemistry. 

Graduate of University of California, Berkeley (Ph.D., 2010)

Postdoctoral Fellow & Centenary Research Fellow, University of Melbourne (2010-2012)

Lecturer, University of New South Wales (2013-2016)

Senior Lecturer, University of New South Wales (2016-current)


International Union of Pure and Applied Chemistry Prize for Young Chemists (2011)

New South Wales Fresh Science Finalist (2013)

ARC Discovery Early Career Researcher Award (2013-2015)

Australian and New Zealand Society for Mass Spectrometry Michael Guilhaus Research Award (2015) 

Emerging Investigator, Analytical Methods (2015)

Emerging Investigator, Analyst (2016)

Emerging Investigator, Journal of the American Society for Mass Spectrometry (2016)

RACI Physical Chemistry Division Lectureship (2016)

RACI Analytical and Environmental Chemistry Division Peter W. Alexander Medal (2016)

Service Roles and Professional Organisations

Treasurer, Australian and New Zealand Society for Mass Spectrometry

Chair, Royal Australian Chemical Institute, NSW Analytical and Environmental Chemistry Group

Editorial Board (Diagnostics and Bioanalytical Chemistry), Expert Opinion on Therapeutic Patents

Editorial Board, Journal of Enzyme Inhibition and Medicinal Chemistry

Book Editor, Comprehensive Analytical Chemistry 

Member, Australian Centre for NanoMedicine

Member, Royal Australian Chemical Institute

Member, Australian and New Zealand Society for Mass Spectrometry

Member, American Chemical Society

Member, American Society for Mass Spectrometry


Course Coordinator and Lecturer, Analytical Chemistry: Frontier Techniques (Third Year Level)

Lecturer, Analytical Chemistry: Essential Methods (Second Year Level)

Lecturer, Chemistry A: Atoms, Molecules and Energy (First Year Level)

Lecturer, Higher Chemistry A: Atoms, Molecules and Energy (First Year Level)

Current Research Grants

WA Donald, CT Supuran; Rapid, Ultra-sensitive Protein Structure Elucidation by Mass Spectrometry; ARC Discovery Project; 2016-2018

NSW Smart Sensing Network

Selected Publications

1. Zenaidee, M. A.; Leeming, M. G.; Zhang, F.; Funston, T. T.; Donald, W. A. Highly charged protein ions: The strongest organic acids to date. Angewandte Chemie International Edition, 2017, DOI: 10.1002/anie.201702781 ("Very Important Paper").

2. Kabir, K. M. M.; Donald, W. A. Microscale differential ion mobility spectrometry for field deployable chemical analysis. Trends in Analytical Chemistry, 2017, DOI: 10.1016/j.trac.2017.10.0112. 

3. Dumlao, M. C.; Xiao, D.; Zhang, D.; Fletcher, J.; Donald, W. A. Effects of different waveforms on the performance of active capillary dielectric barrier discharge ionization mass spectrometry. Journal of the American Society for Mass Spectrometry, 2017, 28, 575-78 (Cover of Emerging Investigator Issue).

4. Leeming, M. G.; Donald, W. A.; O'Hair, R. A. J. Non-targeted identification of reactive metabolite protein adducts. Analytical Chemistry, 2017, DOI: 10.1021/acs.analchem.6b04604.

5. Dumlao, M. C.; Jeffress, L. E.; Gooding, J. J.; Donald, W. A. Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures. Analyst, 2016, 141, 3714-21 (Emerging Investigator Issue).

6. Leeming, M. G.; Isaac, A. P.; Pope, B. J.; Cranswick, N.; Wright, C. E.; Ziogas, J.; O'Hair, R. A. J.; Donald, W. A. High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing. Analytical Chemistry, 2015, 87, 4104-09.

7. Zenaidee, M. A.; Donald, W. A. Extremely supercharged proteins in mass spectrometry: profiling the pH of electrospray generated droplets, narrowing charge state distributions, and increasing ion fragmentation. Analyst, 2015, 140, 1894-905.

8. Zenaidee, M. A.; Donald, W. A. Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation. Analytical Methods, 2015, 7, 7132 (Emerging Investigator Issue).

9. Teo, C. A.; Donald, W. A. Solution Additives for Supercharging Proteins Beyond the Theoretical Maximum Proton-Transfer Limit in Electrospray Ionization Mass Spectrometry. Analytical Chemistry, 2014, 86, 4455-62.

10. Hoi, K. K.; Daborn, P. J.; Battlay, P.; Robin, C.; Batterham, P.; O’Hair, R. A. J.; Donald, W. A. Dissecting the insect metabolic machinery using twin ion mass spectrometry: A single P450 enzyme metabolizing the insecticide imidacloprid in vivoAnalytical Chemistry, 2014, 86, 3525-32.

Complete publication list: