Adam Martin

Adam Martin

Adam Martin

Lecturer and NHMRC-ARC Dementia Research Development Fellow

Contact details

Phone: +61 9385 4660
Email: adam.martin2@unsw.edu.au

Office

Room 126, Dalton Building F12

UNSW, Kensington, 2052

 

Research Group website

https://admartingroup.wordpress.com/

Biographical Details

Adam Martin completed his PhD at UWA in 2011 with Professor Colin Raston in the area of supramolecular chemistry. He then commenced a postdoctoral position at the University of Nottingham with Professor Martin Schröder synthesising novel ligands for new metal organic frameworks. In 2013 he moved to the University of New South Wales to work with Professor Pall Thordarson on deciphering the desgin rules in short peptide hydrogels. In 2016 he was awarded an NHMRC-ARC Dementia Research Fellowship to use these scaffolds for culturing sensitive primary neurons, thus gaining insights into the early stages of Alzheimer's Disease. He was promoted to Lecturer in early 2018.

Research Interests

My research designs hydrogels which mimic the extracellular matrix. The extracellular matrix (ECM) plays a vital role in supporting the body’s cells, existing as a fibrous mesh which provides both physical and chemical cues that control cell behaviour. Here, I aim to make better ECM mimics by controlling both the physical and chemical nature of short peptides which self-assemble to fibres. This will ultimately lead to hydrogels which can be tailored towards different areas of the body, allowing for better implants, wound healing and tissue regeneration.

Self-assembly

 





 

These hydrogels can be used to produce better disease models. It is known that current 2D cell culture fails to capture many of the properties exhibited by cells in vivo. By culturing cells within three dimensional hydrogels, a more accurate representation of the environment within the body can be obtained. This can give insights into ageing and different diseases (including various dementias), and better drug screening.

Neurons








 

 

I also have research interests in gene delivery, mechanobiology, crystal engineering, metal organic frameworks and supramolecular chemistry in general. 

Selected publications

For a full list of publications, please see my Google Scholar profile at https://scholar.google.com.au/citations?user=CvUNMNwAAAAJ&hl=en

  • McEwen, H., Du, E. Y., Mata, J., Thordarson, P., Martin, A. D., “Tuning hydrogels through metal-based gelation triggers”, J. Mater. Chem. B, 2017, doi: 10.1039/C7TB02140B.
  • Moir, M., Chua, S. W., Reekie, T., Martin, A. D., Ittner, A., Ittner, L. M., Kassiou, M., “Ring-opened aminothienopyridazines as novel tau aggregation inhibitors´, MedChemComm, 2017, 8, 1275-1282.
  • Martin, A. D., Wojciechowski, J. P., Robinson, A. B., Heu, C., Garvey, C. J., Ratcliffe, J., Waddington, L. J., Gardiner, J., Thordarson, P., “Controlling self-assembly of diphenylalanine peptides at high pH using heterocyclic capping groups", Sci. Rep., 2017, 43947.
  • Barker, E. C., Martin, A. D., Garvey, C. J., Goh, C. Y., Jones, F., Mocerino, M., Skelton, B. W., Ogden, M. I., Becker, T., “Thermal annealing behaviour and gel to crystal transition of a low molecular weight hydrogelators”, Soft Matter, 2017, 13, 1006-1011.
  • Martin, A. D., Easun, T. L., Argent, S. P., Lewis, W., Blake, A. J., Schroder, M., "The effect of carboxylate position on the structure of a metal-organic framework derived from cyclotriveratrylene", CrystEngComm, 2016, 19, 603-609. 
  • Martin, A. D., Wojciechowski, J. P., Bhadbhade, M. M., Thordarson, P., “A capped dipeptide that simultaneously exhibits gelation and crystallization behaviour”, Langmuir, 2016, 32, 2245-2250.
  • Martin, A. D., Wojciechowski, J. P., Warren, H., in het Panhuis, M., Thordarson, P., “Effect of heterocyclic capping groups on the self-assembly of a dipeptide hydrogel”, Soft Matter, 2016, 12, 2700-2707.
  • Martin, A. D., Robinson, A. B., Thordarson, P., “Biocompatible small peptide super-hydrogelators bearing carbazole functionalities” J. Mater. Chem. B., 2015, 3, 2277-2280.
  • Martin, A. D., Britton, J., Easun, T. L., Blake, A. J., Lewis W., Schroder, M., “Hirshfeld surface investigation of structure directing interactions within dipicolinic acid derivatives”, Cryst. Growth Des., 2015, 15, 1697-1706.
  • Martin, A. D., Robinson, A. B., Mason, A. F., Wojciechowski, J. P., Thordarson, P., “Exceptionally strong hydrogels through self-assembly of an indole-capped dipeptide” Chem. Commun., 2014, 50, 15541-15544.
  • Martin, A. D., Raston, C. L., ‘Multifunctional p-Phosphonated Calixarenes’, Chem. Commun., 2011, 47, 9764-9772.
  • Martin, A. D., Boulos, R. A., Hubble, L. H., Hartlieb, K. J., Raston, C. L., ‘Multifunctional Water-soluble Molecular Capsules Based on p-Phosphonic Acid Calix[5]arene’, Chem. Commun., 2011,47, 7353-7355.