Kumar Group

PROF. NARESH KUMAR
Level 2, Dalton Building (F12)
T: 9385 4698 E: n.kumar@unsw.edu.au

SYNTHETIC ORGANIC and MEDICINAL CHEMISTRY
The main focus of the research undertaken in my group is the discovery and development of novel bioactive molecules. Naturally produced chemicals are of fundamental importance in biological systems. Such chemicals are used to mediate interactions across all levels of biological hierarchy.  Very often such diverse molecules are produced only in minute quantities. New or innovative organic syntheses not only provide access to sufficient quantities of these molecules but also their analogues.  The access to various structurally-related analogues allows full assessment of their biological activity and mode of action, and offers opportunities to develop new therapeutic leads.  The research is multi-disciplinary in nature and involves a combination of synthetic organic chemistry, molecular modelling and biological screening.

(a)      DESIGN AND SYNTHESIS OF NOVEL ANTIMICROBIAL AGENTS
Quorum Sensing Inhibitors


The emergence of multi-drug resistance in common human pathogens has highlighted the need to develop novel classes of antimicrobials for the treatment of human disease. A number of projects are available in this area focussing on a combination of organic synthesis, molecular modelling, and in vitro and in vivo antimicrobial screening. This project will develop novel antagonists of bacterial signalling pathways, which inhibit the regulatory quorum sensing communication pathways of bacteria, and will model the receptor-ligand interaction using the X-ray crystal structures of bacterial signal receptors e.g. AHL receptor LasR. This represents a non-growth inhibition strategy that is less likely to result in the development of drug resistance1. In particular, this proposal will investigate the design and synthesis of a range of novel heterocyclic compounds with antimicrobial activity.

New scaffolds for antimicrobial discovery
(in collaboration with Prof. David StC Black)


The majority of conventional antibiotics used today share a common feature in that they act on specific molecular targets. Having very well-defined targets, these drugs act with a high degree of selectivity, minimizing unwanted side effects. However, a major limitation of antibiotics targeting a single receptor is the ease with which resistance can be developed. The central aim of this project is to design novel small molecular antimicrobial peptide (SMAMP) mimics based on glyoxylamides2, which disrupt the normal functioning of the membranes of the bacterial cell, and as a consequence allow the development of antimicrobial agents with enhanced activity and the ability to bypass resistance mechanisms used by bacteria against other antibiotic types.

Inhibitors of Bacterial Transcription Initiation
(in collaboration with A/Prof. Renate Griffith, UNSW and Prof. Peter Lewis, University of Newcastle)


The enzyme RNA polymerase (RNAP) that transcribes DNA into RNA is highly conserved across species. However, the factors that regulate the activity of RNAP are target-specific. Therefore, the unique interaction of sigma factors with RNAP in bacteria represents an ideal target for the development of small molecules that can specifically inhibit this interaction3. In this project new molecules that target these essential protein-protein interactions will be rationally designed and synthesized, and evaluated for their antimicrobial efficacy. These new small molecules would represent lead compounds for the development of new antibiotics.

(b)    DEVELOPING ANTICANCER COMPOUNDS THAT ACTIVATE GLUCOSE OXIATION
(in collaboration with Dr Kyle Hoehn, BABS, UNSW)


Cancer is a major burden of disease, affecting the lives of tens of millions on a global scale. A hallmark feature of nearly all cancer cells is their altered metabolism of glucose compared to non-cancerous cells. Relative to most normal cells, cancer cells use a greater proportion of incoming glucose for non-oxidative purposes including the production of building blocks for cell division (lipid, DNA and protein), rather than oxidative pathways that produce carbon dioxide (CO2) in mitochondria. The goal of this proposal is to develop anticancer molecules that change cancer cell glucose metabolism to be more like that of non-cancerous cells. We have identified a small molecule that increases glucose oxidation and selectively kills cancer cells in vitro and in mice. The aim of this project is to generate new derivatives with enhanced activity and drug-like properties. The new compounds will be evaluated for anticancer activity in various cancer cell lines.

(c)    DESIGN AND SYNTHESIS OF NOVEL ANTIMALARIAL AGENTS
(in collaboration with Prof David Black)


Flavones and isoflavones are two structurally related large and diverse groups of natural compounds with broad spectra of biological activities including antioxidant, anticancer, antiviral and anti-inflammatory properties. They are recognized as “privileged” medicinal chemistry molecular frameworks because they are commonly found in biologically active compounds that show drug-like characteristics. Dependensin is a dimeric flavonoid isolated from the rootbark of a Tanzanian medicinal plant, Uvaria dependens. The crude extract of this plant shows potent antimalarial activity. Our group has reported the successful synthesis of dependensin via the acid-catalyzed reaction of 5,7,8-trimethoxyflavene. A number of projects are available in this area focussing on the design, synthesis and evaluation of antimalarial activity of new azaflavone analogues in which the ring oxygen atoms are replaced by nitrogen atoms.

Novel Anti-Microbial Biomaterials
(in collaboration with Prof Mark Willcox, OPTOM, UNSW)
The use of medical devices has increased immensely over the last decade.  Although, this increase in device use has resulted in a better quality of life and longer patient survival, device-related bacterial infections have emerged as a serious problem with the increased use of medical implants. Once in an established biofilm, bacteria are more resistant to antibiotic treatment and the host immune system. The aim of this project is to develop methodologies for the covalent attachment of novel anti-microbial compounds including specially designed peptides or small heterocyclic compounds onto biomaterial surfaces. Initially the attachment chemistry will be optimised using glass as a model surface, and subsequently the methodology will be adapted for the contact lenses and silicone rubber surfaces. The resulting biomaterials will be characterised by various surface analysis techniques including XPS and ATR spectroscopy, and assessed for anti-microbial efficacy in collaboration with the microbiology partners.

Development of Novel Environmentally Benign Technologies for the Control of Biofilms in Industrial Applications
There is an imperative to develop environmentally compatible strategies to control bacterial biofilms on industrial surfaces. For example, biofim mediated corrosion affects a range of industries, from oil distribution to food processing surfaces and has been estimated to result in added costs of between US$20-300 billion per year in the USA alone.  Biofilms also form on membrane surfaces, such as in reverse osmosis plants, where the associated biomass block the membrane pores.  Fouling increases the water pressure required to continue filtration, significantly increasing the cost of water purification.  When fouling occurs, water purification systems must be shut-down for chemical disinfection and back flushing to alleviate fouling. The current state of the art for the removal of biofilms from pipelines, membranes and food handling surfaces typically include either alone or in combination, mechanical scrubbing, such as ‘pigs’ or brushes as well as harsh chemicals, many of which are highly toxic, such as glutaraldehyde. These low-tech approaches are typically not effective at removing biofilms which are significantly more resistant than free living bacteria.

Recently, it has been shown that by exogenously adding small molecules that generate nitric oxide (NO), generically called NO donors, it is possible to induce the dispersal of surface associated bacteria and biofilms in a number of bacteria. The aim of this project is to deliver nitric oxide (NO) donating molecules directly on surfaces using coatings or co-polymers for the control of biofilms on surfaces.


Research Publications 2010-2016

  1. Chen R, Willcox MDP, Ho KKK, Smyth D, Kumar N. (2016). Antimicrobial peptide melimine coating for titanium and its in vivo antibacterial activity in rodent subcutaneous infection models. Biomaterials, 85: 142-151. IF: 8.4
  2. Nizalapur S, Kimyon O, Biswas NN, Gardner CR, Griffith R, Rice S, Manefield M, Willcox MDP, Black DStC, Kumar N, (2016) Design, synthesis and evaluation of N-arylglyoxylamides derivatives as structurally novel bacterial quorum sensing inhibitors, Organic & Biomolecular Chemistry, 14:680-693. IF: 3.6
  3. Bingul M, Kumar N, Black DStC, (2016) Synthesis and reactions of new 2- hydroxymethyl- dimethoxyindoles, Tetrahedron, 72:234-239. IF: 3.0
  4. Biswas NN, Kutty SK, Iskander GM, Mielczarek M, Bhadbhade M, Gardner CR, Black DStC, Kumar N, (2016) Synthesis of brominates novel N-heterocycles: new scaffolds for antimicrobial discovery, Tetrahedron, 72:539-546. IF: 3.0
  5. Al-Eisawi, Z, Stefani C, Jansson, PJ, Arvind A, Sharpe PC, Basha MT, Iskander GM, Kumar N, Kovacevic Z, Lane DJR, Sahni S, Bernhardt PV, Richardson DR, Kalinowski DS, (2016) Novel mechanism of cytotoxicity for the selective selenosemicarbazone, 2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone (Ap44mSe): lysosomal membrane permiabilization, Journal of Medicinal Chemistry, 59:294-312. IF: 5.45
  6. Nguyen, TK, Selvanayagam R, Ho KKK, Chen R, Kutty SK, Rice S, Kumar N, Barraud N, Duong HTT, Boyer C, (2016) Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles, Chemical Science, 7:1016-1027. IF: 9.2
  7. Thach O, Mielczarek M, Ma C, Kutty S, Yang X, Black DStC, Griffith R, Lewis PJ, Kumar N. (2016 From indole to pyrrole, furan, thiophene and pyridine: Search for novel small molecule inhibitors of bacterial transcription tnitiation complex formation, Bioorganic & Medicinal Chemistry, in press (21/01/16). IF: 2.9
  8. Dutta D, Kumar N, Willcox MDP. (2015) Antimicrobial activity of four cationic peptides immobilized to poly-hydroxyethylmethacrylate. Biofouling. In Press (17/11/15) IF: 3.4
  9. Iskander G, Wood K, Eiffe E, Yee, EMH, Black DStC, Kumar N, (2015) Ritter reactions of isoflavanols: a facile route to 4-amidoisoflavans, Tetrahedron Letters, 56(15):1941-1943. IF: 2.7
  10. Mielczarek M, Thomas RV, Ma C, Kandemir H, Yang X, Bhadbhade M, Black DStC, Griffith R, Lewis P, Kumar N, (2015) Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation, Bioorganic & Medicinal Chemistry, 23(8):1763-1775. IF: 2.9
  11. Das D, Kutty SK, Tavallaie R, Panchompoo J, Sehar S, Aldous L, Yeung A, Thomas S, Kumar N, Gooding JJ, Manfield M, (2015) Bacterial pathogen secondary metabolite interaction with extracellular DNA and interruption with antioxidants, Nature Scientific Reports, 5 (8398): 1-9. IF: 5.3
  12. Biswas NN, Kutty SK, Barraud N, Iskander GM, Griffith R, Rice S, Willcox M, Black DStC, Kumar N., (2015) Indole-based novel small molecules for the modulation of bacterial signalling pathways, Organic & Biomolecular Chemistry, 13:925-937. IF: 3.6
  13. Kutty, SK, Barraud N, Ho, KKK, Iskander GM, Griffith R, Rice S, Bhadbhade M, Willcox M, Black DStC, Kumar N, (2015) Hybrids of acylated homoserine lactone and nitric oxide donors as inhibitors of quorum sensing and virulence factors in Pseudomonas aeruginosa, Organic & Biomolecular Chemistry, 13:9850-9861. IF: 3.6
  14. Chen Y, Cass SL, Kutty SK, Yee EMH, Chan DSH, Gardner CR, Vittorio O, Pasqueir E, Black DStC, Kumar N, (2015) Synthesis, biological evaluation and structure-activity relationship studies of isoflavene based Mannich bases with potent anticancer activity, Bioorganic & Medicinal Chemistry, 25:5377-5383. IF: 2.9
  15. Pandika K, Koshy P, Ho KKK, Kumar N, and Sorrell CC, (2015) Photocatalytic TiO2 Thin Films on Fluorinated Ethylene Propylene Copolymer (FEP) Substrates, J. Aust. Ceram. Soc., 51(2), p. 160-170.
  16. Mielczarek M, Bhadbhade M, Chen R, Kumar N, Black DStC, (2015) Bromination of 2,7’-bi-indolyls and quinazolin-7-ones, Tetrahedron, 71:8925-8942. IF: 3.0
  17. Goh, Wai-Kean, Gardner CR, Chandra Sekhar KVG, Biswas NN, Nizalapur S, Rice SA, Willcox M, Black DStC, Kumar N, (2015) Synthesis, quorum sensing inhibition and docking studies of 1,5-dihydropyrrol-2-ones, Bioorganic & Medicinal Chemistry, 23:7366-7377. IF: 2.9
  18. Hong K, Ball G, Black DStC, Kumar N, (2015) The Mosaic of Rotterlin, J. Org. Chem, 80:10668-10674. IF: 5.4
  19. Suryanti V, Bhadbhade M, Chawla HM, Howe E, Thordarson P, Black DStC, Kumar N. (2014) Novel colorimetric anion sensors based on N-acetylglyoxylic amides containing nitrophenyl signalling units, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 121, 662-669. IF: 1.9
  20. *Ho KKK, Chen R, Willcox MDP, Rice SA, Cole N, Iskander G, Kumar N. (2014) Quorum sensing inhibitory activities of surface immobilized antibacterial dihydropyrrolones via click chemistry, Biomaterials, 35(7), 2336-2345. IF: 8.4
  21. Rajput S, Gardner CR, Failes TW, Arndt GM, Black DStC, Kumar N. (2014) Synthesis and anticancer evaluation of 3-substituted quinolin-4-ones and 2,3-dihydroquinolin-4-ones, Bioorganic & Medicinal Chemistry, 22(1), 105-115. IF: 2.9
  22. Kutty S, Bhadbhade M, Iskander G, Black DStC, Kumar N. (2014) An unusual synthesis and crystal interaction studies of a highly functionalized thiophene system. Tetrahedron Letters. 55:3916-3919. IF: 2.7
  23. Duong H, Adnan N, Barraud N, Basuki J, Kutty S, Jung K, Kumar N, Davis T, Boyer C. (2014) Functional gold nanoparticles for the storage and controlled release of nitric oxide: applications in biofilm dispersal and intracellular delivery. J Materials Chem B. 2:5003-5011.
  24. Duong, H, Jung K, Kutty S, Agustina S, Adnan N, Basuki J, Kumar N, Barraud N, Davis T, Boyer C. (2014) Nanoparticle (Star Polymer) delivery of nitric oxide effectively negates Pseudomonas aerugunosa biofilm formation. Biomacromolecules. 15:2583-2589. IF: 5.8
  25. Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR. (2014) Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: Structure–activity relationship studies on their anti-proliferative and iron chelation efficacy, Journal of Inorganic Biochemistry, 141: 43-54. IF: 3.4
  26. Chawla HM, Shahid, M, Black DStC, Kumar N. (2014) A new calix[4]arene based molecular probe for selective and sensitive detection of CN? ions in aqueous media, New Journal of Chemistry, 38(7):2763-2765. IF: 3.2
  27. Chawla HM, Kar JR, Siddiqui WA, Black DStC, Kumar N. (2014) A new calix[4]arene based nucleobase for cation recognition, Tetrahedron Letters, 55(33):4517-4520. IF: 2.7
  28. Saddiqa A, Raza AR, Black DStC, Kumar N. (2014) Chiron based synthesis of isocoumarins: reactivity of ?-substituted carboxylic acids, Tetrahedron: Asymmetry, 25:736-743. IF: 2.1
  29. Mielczarek M, Devakaram RV, Ma C, Yang X, Kandemir H, Purwono B, Black DStC, Griffith R, Lewis PJ, Kumar N. (2014) Synthesis and biological activity of novel bis-indole inhibitors of bacterial transcription initiation complex formation, Organic & Biomolecular Chemistry, 12(18):2882-2894. IF: 3.6
  30. Chawla HM, Geol P, Shukla R, Black DStC, Kumar N. (2014) New lower rim looped calix[4]arene for ratiometric and chromogenic recognition of Cu2+, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 80(3-4):201-207. IF: 1.9
  31. Kandemir H, Ma C, Kutty SK, Black DStC, Griffith R, Lewis PJ, Kumar N. (2014) Synthesis and biological evaluation of 2,5-di(7-indolyl)-1,3,4-oxadiazoles, and 2- and 7-indolyl 2- (1,3,4-thiadiazolyl)ketones as antimicrobials, Bioorganic & Medicinal Chemistry, 22(5):1672-1679. IF: 2.9
  32. Bingul M, Cheung BB, Kumar N, Black DStC. (2014) Synthesis of symmetrical and unsymmetrical diindolylmethanes via acid-catalysed electrophilic substitution reactions, Tetrahedron, 70(40):7363-7369. IF: 3.0
  33. Eiffe E, Pasquier E, Kavallaris M, Herbert C, Black DStC, Kumar N. (2014) Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes, Bioorganic & Medicinal Chemistry, 22(19):5182-5193. IF: 2.9
  34. Suryanti V, Condie GC, Bhadbhade M, Bishop R, Black DStC, Kumar N. (2014) Synthesis, structures, and conformations of linked bis-glyoxylamides derived from bis-acylisatins, Aust J Chem, 67:1270-1278. IF: 1.6
  35. Sengul IF, Somphol K, Kandemir H, Kumar N, Black DStC. (2014) Some electrophilic reactivity studies of di-(2-indolyl)dibenzofurans and di-(2-indolyl)carbazoles, Tetrahedron, 70(51):9601-9614. IF: 3.0
  36. Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR. (2013) Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy. Bioorganic & Medicinal Chemistry Letters. 23:967-974. IF: 2.6
  37. Dutta D, Cole N, Kumar N, Willcox MDP. (2013) Broad spectrum antimicrobial activity of melimine covalently bound to contact lenses. Investigative Ophthalmology & Visual Science 54(1), 175-182. IF: 3.6
  38. Somphol K, Chen R, Bhadbhade M, Kumar N, Black DStC. (2013) A new strategy for calixarene formation: Synthesis of calix[3]indole with 2,2; 7,2; 7,7-methylene linkages and a new calix[4]indole 2,2; 7,2; 7,7; 2,7-methylene linkages. Synlett 24:24-28. IF: 2.71
  39. Kandemir H, Wood K, Kumar N, Black DStC. (2013) Synthesis of 5-(7?-indolyl)oxazoles and 2,5-di-(7?-indolyl)oxazoles. Tetrahedron 69:2193-2198. IF: 3.0
  40. Theerthankar D, Kutty S, Kumar N, Manefield M. (2013) Pyocyanin facilitates extracellular DNA binding to Pseudomonas aeruginosa influencing cell surface properties and aggregation, PloS ONE 8(3), e58299. IF: 4.4
  41. Yee EMH, Pasqueir E, Iskander G, Black DStC, Kumar N. (2013) Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents, Bioorganic &. Medicinal Chemistry. 21(7), 1652-1660. IF: 2.9
  42. Kutty SK, Barraud N, Pham A, Iskander G, Rice SA, Black DStC, Kumar N. (2013) Design, Synthesis, and Evaluation of Fimbrolide-Nitric Oxide Donor Hybrids as Antimicrobial Agents, Journal of Medicinal Chemistry, 56(23), 9517-9529. IF: 5.6
  43. Nisar B, Raza AR, Black DStC, Kumar N, Tahir MN. (2013) Stereoselective Synthesis of (3R)-3-Alkyl-4,1-Benzoxazepine-2,5-Diones, Chirality 25(12), 865-870. IF: 2.3
  44. Chen R, Somphol K, Bhadbhade M, Kumar N, Black DStC. (2013) Synthesis of semicalix[4]indoles containing combinations of direct links and methylene linkages, Synlett (2013), 24(12), 1497-1500. IF: 2.6
  45. Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR. (2013) Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective antitumour activity Organic & Biomolecular Chemistry, 11(37), 6414-6425. IF: 3.6
  46. Suryanti V, Bhadbhade M, Bishop R, Black DStC, Kumar N. (2013) Chirality of the molecular assembly determined by intra-/inter-N-H···O hydrogen bonding in doubly substituted Noctanoylglyoxylic amides, Tetrahedron 69(39), 8446-8455. IF: 3.0
  47. Ma C, Yang X, Kandemir H, Mielczarek M, Johnston EB, Griffith R, Kumar N, Lewis PJ. (2013) Inhibitors of bacterial transcription initiation complex formation, ACS Chemical Biology, 8(9), 1972-1980. IF: 6.0
  48. Sinha S, Mishra P, Amin H, Rah B, Nayak D, Goswami A, Kumar N, Vishwakarma R, Ghosal S. (2013) A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: Study of anti-proliferative and apoptosis inducing property, European Journal of Medicinal Chemistry  60, 490-496. IF: 3.5
  49. Chen R, Willcox MDP, Cole N, Ho KKK, Rasul R, Denman JA, Kumar N. (2012) Characterization of chemoselective surface attachment of the cationic peptide melimine and its effects on antimicrobial activity. Acta Biomaterialia 8:4371-4379. IF: 4.9
  50. Chen R, Bhadbhade M, Kumar N, Black DStC. (2012) Synthesis of macrocyclic tetraindolyls via oxidative coupling reactions. Tetrahedron Letters. 53:3337-3341. IF: 2.7
  51. Chawla HM, Santra A, Pant N, Kumar S, Kumar N, Black DStC. (2012) Evaluation of deep cavity imidazolylcalix[n]arenes for selective extraction of silver. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 73:55-65. IF: 1.9
  52. Deodhar M, Wood K, Black DStC, Kumar N. (2012) Synthesis of oxygenated 4- arylisoflavans and 4-arylflavans. Tetrahedron Letters. 53:6697-6700. IF: 2.7
  53. Deodhar M, Wood K, Black DStC, Kumar N. (2012) Oxidative Dimerisation of Isoflavones: Synthesis of Kudzuisoflavone A and Related Compounds. Australian Journal of Chemistry. 65:1377-1383. IF: 2.3
  54. Sengul IF, Wood K, Bowyer PK, Bhadbhade M, Chen R, Kumar N, Black DStC. (2012) Synthesis of new di-(3-indolyl)arenes. Tetrahedron. 68:7429-7434. IF: 3.0
  55. Devakaram R, Black DStC, Choomuenwai V, Davis RA, Kumar N. (2012) Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b]chromene derivatives. Bioorganic & Medicinal Chemistry 20: 1527-1534. IF: 2.9
  56. Somphol K, Santoso M, Bhadbhade M, Gardner C, Kumar N, Black DStC. (2012) Synthesis of mixed cyclotriveratrylenes. Tetrahedron 68:1862-1868. IF: 3.0
  57. Devakaram R, Black DStC, Kumar N. (2012) An efficient synthesis of novel 2,4-disubstituted tetrahydroquinolines and quinolines, Tetrahedron Letters 53(18): 2269-2272. IF: 2.7
  58. Gardner CR, Cheung BB, Koach J, Black DStC, Marshall GM, Kumar N. (2012) Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy. Bioorganic & Medicinal Chemistry. 20:6877-6884. IF: 2.9
  59. Ho K, Cole N, Chen R, Willcox MDP, Rice S, Kumar N. (2012) Immobilisation of antibacterial dihydropyrrol-2-ones onto functional polymer supports to prevent bacterial infections in vivo. Antimicrobial Agents and Chemotherapy 56(2): 1138-1141. IF: 4.7
  60. Mitchell PSR, Sengul IF, Kandemir H, Nugent SJ, Chen R, Bowyer PK, Kumar N, Black DStC. (2012) Bromination of 4,6-dimethoxyindoles. Tetrahedron. 68:8163-8171. IF: 3.0
  61. Sengul IF, Wood K, Kumar N, Black DStC. (2012) Synthesis of macrocyclic systems derived from di-(2-indolyl)heteroarenes. Tetrahedron. 68:9050-9055. IF: 3.0
  62. Suryanti V, Bhadbhade M, Bishop R, Black DStC, Kumar N. (2012) Self-assembly of alkyl N-acetylglyoxylic amides of varying chain lengths. CrystEngComm. 14:7345-7354. IF: 3.8
  63. Deodhar M, Black DStC, Chan DSH, Kumar N. (2011) Synthesis of new biheterocycles by a one-pot sonogashira coupling reaction. Heterocycles 82:1489-1501. IF: 1.0
  64. Chawla HM, Kumar S, Pant N, Santra A, Srinivas A, Kumar N, Black DStC. (2011) Synthesis and evaluation of deep cavity imidazolyl calix[n]arenes. J. Incl. Phenom. and Macrocyclic Chem. 71:169-178. IF: 1.1
  65. Zhang R, Iskander G, da Dilva P, Chan D, Vignevich V, Nguyen V, Bhadbhade M, Black DStC, Kumar N. (2011) Synthesis of new aryl substituted furan-2(5H)-ones using the Suzuki-Miyaura reaction. Tetrahedron 67: 3010-3016. IF: 3.0
  66. Wood K, Black DStC, Kumar N. (2011) Ring closing metathesis strategies towards functionalized 1,7-annulated 4,6-dimethoxyindoles. Tetrahedron 67: 4093-4102. IF: 3.0
  67. Le T, Cheah WC, Wood K, Black DStC, Willcox MD, Kumar N. (2011) Synthesis of dendrimeric N-glyoxylamide peptide mimics. Tetrahedron Letters 52: 3645-3647. IF: 2.7
  68. Devakaram R, Black DStC, Andrews KT, Fisher GM, Davis RA, Kumar N. (2011) Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives. Bioorganic & Medicinal Chemistry 19: 5199-5206. IF: 2.9
  69. Cheah WC, Wood K, Black DStC, Kumar N. (2011) Facile ring-opening of N-acylisatins for the development of novel peptidomimetics. Tetrahedron 67: 7603-7610. IF: 3.0
  70. Chawla HM, Pant N, Kumar S, Mrig S, Santra A, Srivastava B, Kumar N, Black DStC. (2011) Synthesis and evaluation of novel tetrapropoxycalix[4]arene enones and cinnamates for protection from ultraviolet radiation. J. Photochemistry Photobiology, B: Biology 105:25-33. IF: 2.1
  71. Rajput S, Leu C-W, Wood K, Black DStC, Kumar N. (2011) Facile syntheses of 7,9-dimethoxypyrrolo[3,2,1-ij]quinolin-6-ones. Tetrahedron Letters 52: 7095-7098. IF: 2.7
  72. Deodhar M, Black DStC, Chan DSH, Kumar N. (2010) Synthesis of some new biheterocycles by a one-pot Suzuki-Miyaura coupling reaction. Heterocycles 80:1267-1274. IF: 1.0
  73. Wood K, Black DStC, Namboothiri INN, Kumar N. (2010) Synthesis of novel 1,7-annulated 4,6-dimethoxyindoles. Tetrahedron Letters 51:1606-1608. IF: 2.7
  74. Cole N, Hume EBH, Vijay AK, Sankaridurg P, Kumar N, Willcox MDP. (2010) In vivo performance of melimine as an antimicrobial coating for contact lenses in models of CLARE and CLPU. Investigative Ophthalmology & Visual Science 51:390-395. IF: 3.9
  75. Rasul R, Cole N, Balasubramanian R, Chen R, Kumar N, Willcox MDP. (2010) Interaction of the antimicrobial peptide melimine with bacterial membranes. International Journal of Antimicrobial Agents. 35:566-572. IF: 3.1
  76. Pinkerton DM, Banwell MG, Garson MJ, Kumar N, de Moraes MO, Cavalcanti BC, Barros FWA, Pessoa C. (2010) Antimicrobial and cytotoxic activities of synthetically derived Tambjamines C and E-J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata. Chemistry and Biodiversity. 7: 1311-1324. IF: 1.6
  77. Devakaram R, Black DStC, Kumar N. (2010) An efficient synthesis of novel tetrahydrochromeno[2,3-b]chromenes. Tetrahedron Letters. 51:3636-3638. IF: 2.7
  78. Wood K, Black DStC, Kumar N. (2010) Acid-Catalyzed Reactions of 3-Substituted-4,6-dimethoxyindoles with Ketones. Aust J Chem. 63:761-770. IF: 2.0
  79. Kutty S, Bhadbhade M, Iskander G, Bishop R, Griffith R, Black DStC, Kumar N. (2010) Fimbrolide disulfanes: synthesis and crystal interactions. Tetrahedron Letters. 51:4856-4858. IF: 2.7
  80. Ho K, Cole N, Chen R, Willcox MDP, Rice S, Kumar N. (2010) Characterisation and in vitro activities of surface attached dihydropyrrol-2-ones against Gram-negative and Gram positive bacteria. Biofouling 26:913-921. IF: 4.415