Optimal drug loading of tumour-targeting nanoparticles

Posted 2 August 2017

Payload size influences the therapeutic impact of drug-loaded nanoparticles, and it is not neccessarily in the way that we would expect, says Scientia Professor Martina Stenzel.

When designing nanocarriers for drug delivery, nanoparticle size, shape, and surface chemistry are not the only attributes affect performance. Using solid-state NMR spectroscopy, the team led by Stenzel discovered that large loads of platinum-based drugs caused structural changes to polymer micelles, which impair uptake by cancer cells, and killing capacity.

This unexpected discovery was reported in Angewandte Chemie, International, and further highlighted in the ChemViews Magazine.

Read the ChemViews story here

And the full research communication here.