Cell and Matrix Engineering
Cell state in tissue is ruled by a multivariate presentation of signals that orchestrate diverse forms and functions. Using hydrogel microengineering we are exploring how biochemical, biophysical, and biological cues in the cell and tissue microenvironment orchestrate cell state, matrix synthesis, and hierarchical assembly.
Cell Responsive Hydrogels
Inspired by how forces in tissue guides matrix deposition and release of sequestered molecules, we aim to develop bioinspired chemistry where an applied force facilitates biomolecule immobilisation and/or release through distinct chemical handles built into the synthetic hydrogel network.
Biomimetic Composite Materials
Our tissues are composed of composite materials of biopolymers and ceramic structures, with hierarchical order for guiding cell and tissue organization. Using micro- and nano- fabrication techniques we design and develop composite biomaterials that recapitulate these architectures.
Additive Bioassembly
The form and function of tissue is nurtured through a complex bi-directional interplay between cells and materials. We recognise the critical aspects of both of these parts and work to develop strategies that combine ‘cell engineering’ with ‘biofabrication’ to coax the cells and materials to assemble together.
Recent news
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Selected Publications
